Periostin promotes a fibroblastic lineage pathway in atrioventricular valve progenitor cells
نویسندگان
چکیده
منابع مشابه
ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor.
ETV6-RUNX1 gene fusion is usually an early, prenatal event in childhood acute lymphoblastic leukemia (ALL). Transformation results in the generation of a persistent (> 14 years) preleukemic clone, which postnatally converts to ALL after the acquisition of necessary secondary genetic alterations. Many cancer cells show some expression of the erythropoietin receptor (EPOR) gene, although the "fun...
متن کاملProgenitor cells and valve degeneration.
To the Editor: We read with great interest the study by Visconti et al,1 that tested in a mice model whether hematopoietic stem cells (HSCs) may contribute to cardiac valve interstitial cells. Based on the finding that HSC-derived cells within the valves exhibited synthetic properties characteristic of fibroblasts, the investigators concluded that HSCs are a source of valve fibroblasts. These e...
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Stem cells have been widely used in tendon tissue engineering. The lack of refined and controlled differentiation strategy hampers the tendon repair and regeneration. This study aimed to find new effective differentiation factors for stepwise tenogenic differentiation. By microarray screening, the transcript factor Fos was found to be expressed in significantly higher amounts in postnatal Achil...
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Pulmonary vascular disease is characterized by remodeling and loss of microvessels and is typically attributed to pathological responses in vascular endothelium or abnormal smooth muscle cell phenotypes. We have challenged this understanding by defining an adult pulmonary mesenchymal progenitor cell (MPC) that regulates both microvascular function and angiogenesis. The current understanding of ...
متن کاملSurgically created double-orifice left atrioventricular valve: a valve-sparing repair in selected atrioventricular septal defects.
OBJECTIVES Some features of the left atrioventricular valve (large mural leaflet, dystrophic tissue) represent a challenge for repair of atrioventricular septal defects without postoperative regurgitation. A retrospective study was conducted to evaluate the results of surgically creating a double-orifice left atrioventricular valve in such circumstances. Clinical results were analyzed according...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2009
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.21933